<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019ecb99-ae08-7d1c-8e57-dbe9549fa986,g:fb62e381-358c-4e85-85ed-9a72c2880ff4-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.genedx.com/role/DocumentandEntityInformationDocument" xlink:type="simple" xlink:href="wgs-20260615.xsd#DocumentandEntityInformationDocument"/>
  <link:presentationLink xlink:role="http://www.genedx.com/role/DocumentandEntityInformationDocument" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019ecb99-ae08-7c8c-b75e-b044b635e60c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_019ecb99-ae08-70c0-b69d-757c4d4571ad" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntitiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb99-ae08-7c8c-b75e-b044b635e60c" xlink:to="loc_dei_EntitiesTable_019ecb99-ae08-70c0-b69d-757c4d4571ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019ecb99-ae08-7cf7-aa24-fd532aceb6ca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_019ecb99-ae08-70c0-b69d-757c4d4571ad" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019ecb99-ae08-7cf7-aa24-fd532aceb6ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019ecb99-ae08-7dad-a7e8-8d713238ad51" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019ecb99-ae08-7cf7-aa24-fd532aceb6ca" xlink:to="loc_us-gaap_ClassOfStockDomain_019ecb99-ae08-7dad-a7e8-8d713238ad51" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019ecb99-ae08-7ace-8f5e-e8800dd18435" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonClassAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_019ecb99-ae08-7dad-a7e8-8d713238ad51" xlink:to="loc_us-gaap_CommonClassAMember_019ecb99-ae08-7ace-8f5e-e8800dd18435" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_019ecb99-ae08-7322-a780-2d82293bbe41" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_019ecb99-ae08-7dad-a7e8-8d713238ad51" xlink:to="loc_us-gaap_WarrantMember_019ecb99-ae08-7322-a780-2d82293bbe41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityInformationLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_019ecb99-ae08-70c0-b69d-757c4d4571ad" xlink:to="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019ecb99-ae08-7e68-abad-2db1460f08a0" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_DocumentType_019ecb99-ae08-7e68-abad-2db1460f08a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019ecb99-ae08-7607-ac13-a69d971bbcf4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_DocumentPeriodEndDate_019ecb99-ae08-7607-ac13-a69d971bbcf4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019ecb99-ae08-7b48-a6a5-8bc0a0b60959" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_EntityFileNumber_019ecb99-ae08-7b48-a6a5-8bc0a0b60959" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019ecb99-ae08-7c59-ab96-34704946e043" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_EntityRegistrantName_019ecb99-ae08-7c59-ab96-34704946e043" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019ecb99-ae08-798c-98d4-7470b65fa347" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019ecb99-ae08-798c-98d4-7470b65fa347" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019ecb99-ae08-716d-9edc-5da76578037a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_EntityTaxIdentificationNumber_019ecb99-ae08-716d-9edc-5da76578037a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019ecb99-ae08-76ed-b076-13832f0d47df" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_EntityAddressAddressLine1_019ecb99-ae08-76ed-b076-13832f0d47df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_019ecb99-ae08-7a28-8a14-a9262d5e3122" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_EntityAddressAddressLine2_019ecb99-ae08-7a28-8a14-a9262d5e3122" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine3_019ecb99-ae08-7a28-aa23-03a862e7c216" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine3"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_EntityAddressAddressLine3_019ecb99-ae08-7a28-aa23-03a862e7c216" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019ecb99-ae08-791c-8193-f62c9eddc13e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_EntityAddressCityOrTown_019ecb99-ae08-791c-8193-f62c9eddc13e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019ecb99-ae08-73a7-8b20-3e1c375951d9" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_EntityAddressStateOrProvince_019ecb99-ae08-73a7-8b20-3e1c375951d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019ecb99-ae08-7edf-b917-eb2b8e098dad" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_EntityAddressPostalZipCode_019ecb99-ae08-7edf-b917-eb2b8e098dad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019ecb99-ae08-73d1-91e3-7d5b1f4cbab1" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_CityAreaCode_019ecb99-ae08-73d1-91e3-7d5b1f4cbab1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019ecb99-ae08-7c57-aa99-c2d13c634e9b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_LocalPhoneNumber_019ecb99-ae08-7c57-aa99-c2d13c634e9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019ecb99-ae08-7f5f-a44b-93c52a00ed2a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_WrittenCommunications_019ecb99-ae08-7f5f-a44b-93c52a00ed2a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019ecb99-ae08-70cf-9427-2d317e35ae8c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_SolicitingMaterial_019ecb99-ae08-70cf-9427-2d317e35ae8c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019ecb99-ae08-7e05-aa26-51f46e186a62" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_PreCommencementTenderOffer_019ecb99-ae08-7e05-aa26-51f46e186a62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019ecb99-ae08-7eb0-8dc0-dd08b027eed4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019ecb99-ae08-7eb0-8dc0-dd08b027eed4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019ecb99-ae08-77f5-a83f-aff0d33441c5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_Security12bTitle_019ecb99-ae08-77f5-a83f-aff0d33441c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019ecb99-ae08-7789-8712-36bfc4cfefa4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_TradingSymbol_019ecb99-ae08-7789-8712-36bfc4cfefa4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019ecb99-ae08-7b80-8bf8-dd40fc8ab855" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_SecurityExchangeName_019ecb99-ae08-7b80-8bf8-dd40fc8ab855" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019ecb99-ae08-74d6-99af-54b3245149e0" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_EntityEmergingGrowthCompany_019ecb99-ae08-74d6-99af-54b3245149e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019ecb99-ae08-7510-b19d-9ec54bd33734" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_EntityCentralIndexKey_019ecb99-ae08-7510-b19d-9ec54bd33734" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019ecb99-ae08-799c-8022-38ffb0ea0f64" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019ecb99-ae08-7e44-9734-cf490c5a0054" xlink:to="loc_dei_AmendmentFlag_019ecb99-ae08-799c-8022-38ffb0ea0f64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
